Phd Project 9: Analysis of Trna Dynamics Using - Barcelona, España - LongTREC

Descripción

Transfer RNAs (tRNAs) are abundant small non-coding RNAs that play a pivotal role in decoding genetic information, determining which transcripts are highly and poorly translated at a given moment.

Dysregulation of tRNA abundances and their RNA modifications is a well-known feature in cancer cells, which leads to enhanced expression of specific oncogenic transcripts and proteins.

Our laboratory has recently developed a novel approach to studying tRNA populations using native RNA nanopore sequencing technologies (Nano-tRNAseq), providing tRNA abundance, length, and tRNA modification information from the same individual molecules.

Nano-tRNAseq generates powerful and information-rich data, which can in turn be used to predict the biological status (e.g. health, disease, stress) of the cells.

Host:
Center for Genomic Regulation (CRG).

Envisioned secondments:
Oxford Nanopore Technologies (Aino Järvelin), Italian Institute of Technology (Francesco Nicassio,Tommasso Leonardi)


REQUIREMENTS:


Eligibility criteria:

• In all cases, employment will be conditioned to acceptance by the Doctoral school of the associated PhD awarding institution.

ADDITIONAL INFORMATION:


Application and selection process

Applications must contain the following documents (in pdf):

• CV (including publications, if any),

- a motivation letter,

• 2 reference letters,
• Statement in diversity, inclusion, and sustainability,