Bioinformatician 2023/19 - Badalona, España - Instituto de Investigación Germans Trias i Pujol (IGTP)

Instituto de Investigación Germans Trias i Pujol (IGTP)

Empresa verificada

Badalona, España

hace 2 semanas

Publicado por:

Isabel García

beBee Recruiter

Descripción

Referència:

2023/19 Termini:

29/11/2023

JOB DESCRIPTION:

IGTP requires to incorporate to the
_GCAT' Genomes for the Life Lab_ a Post-doctoral fellow for MCIM funded project "Genome Profiling in the GCAT, an electronic health-record population-based cohort study to improve prevention, diagnosis and treatment of common diseases by using PRSs
:GePeTo".

The
GCAT'Genomes for Life conduct its research on human genomics through a wellcharacterised cohort and linked with existing European and international initiatives.
The project
GePeTo, through genome profiling, aims to identify genetic homogenous clusters, to improve disease risk prediction, diagnostic refinement and disease progression, to deploy precision therapeutics and improve strategies based on populationlevel screening.
The project
GePeTo, will define the genetic risk for the whole
_diseasome_ in 20,000 cohort participants, trough the arraygenotyping using last technological developed arrays (1.2M variants) and _i_n silico_ genotyping using the WGS GCAT'Panel, to compute Genomic Risk Scores for all identified diseases (ICD10) and biologic traits using the comprehensive GCAT metadata. Phenomewideassociation, shared genetic analysis, pleiotropic profiling and disease risk representations (decileplot, disease prevalence, etc) will be conducted to disentangle the genetic architecture of human disease. A visualization platform will be also developed.

We are looking for an outstanding person, good nature, with
data science and bioinformatics biology skills, intrepid with interest to work in the analysis of cutting-edge high-throughput OMIC data generated from a
population-based cohort of 20,000 individuals,
linked with existing European and international initiatives.

QUALIFICATIONS AND EXPERIENCIE:

PhD or MSc in Bioinformatics or computer science and experience in bioinformatics software use and/or development (Python, R, and other relevant programming languages)
is required.
Knowledge in computing analysis of OMIC data, database management, statistical analysis, data engineering and visualization in the human health / genome field
is desired

Genome biology background is a plus. Experience working in the field of human genomics, proteomics,
would be acknowledge.
Ability to collaborate with the team and translate existing research into practical solutions and products.
Drive project execution and implement a robust plan for measuring success.

MAIN RESPONSIBILITIES:

The specific tasks will be:

Built a comprehensive map of common genetic variants of 20,000 individuals from the GCAT cohort.
Comprehensive PRSs scoring for all identified medical ICD diagnostic and biologic traits identified in the 20,000 individuals of the GCAT cohort.
Risk clusterization for the GCAT _diseasome_ by genetic risk profiling.
To build a visualization and analysis tool for cohortmining using PRS genetic tools.
To implement webbased tool for _PheWAS_ (Phenome Wide Association Analysis) for GCAT.

WHAT WE OFFER:

24months fulltime contract (desirable extension)
The gross salary commensurate with qualifications of the applicant and consistent with the grant pay scale, distributed in 12 pays, ticket childcare, etc.
23 days of Holidays and 5 personal days per year, Teleworking (1 out 5 days).
Career development opportunities organized by the IGTP.
Join an Excellent multidisciplinary centre awarded with the HRS4R mention.
Join Can Ruti Campus, a unique firstclass translational research and stimulating scientific environment in the nearest Northern Barcelona Area. The IGTP offers a supportive, friendly and collaborative ecosystem, to promote professional development and to achieve personal research objectives.

FOR MORE INFORMATION:

For more information see the link:
/technology-services/gcat/contact

GCAT Genomes for Life - GCAT )

APPLICATIONS:

APPLICATIONS THAT DO NOT INCLUDE THE REFERENCE CODE IN THE SUBJECT LINE WILL NOT BE CONSIDERED