Trabajos
>
Girona

    ADME & DMPK Senior Scientist - Girona, España - Almirall

    Almirall
    Almirall Girona, España

    hace 1 semana

    Almirall background
    Descripción

    Mission

  • Be a member of R&D project teams to provide expert ADME&DMPK support across a project lifecycle in a multidisciplinary environment with special focus between the early stages of drug discovery through candidate nomination and early clinical development.
  • Ensure that ADME profiling, PK/PD, M&S, human dose predictions or other related deliverables are undertaken to best practice standard for study design and decision making to move candidates to preclinical/clinical development.

    • Tasks and Responsibilities

  • Selection, set-up, supervision or incorporation of the appropriate in-vitro/in-vivo models to address ADME/DMPK aspects at all stages from feasibility to candidate nomination and early clinical Development.
  • Responsible for outsourcing and coordination of experimental ADME/DMPK in vitro or in vivo studies when needed.
  • Responsible for all bioanalytical needs, in house or from external vendors, to support ADME/DMPK studies.
  • PK/PD support and use of modeling & simulation tools for human PK predictions enabling human dose projection or safety evaluation.
  • Provide quality data, written reports and presentations, internally or to possible partners, to ensure regular progress updates of ongoing projects. Author high quality reports, including support to regulatory documents, when needed.
  • Collaborate with and support other disciplines across the R&D organization.
  • Maintain an up-to-date knowledge of the relevant scientific literature as well as regulatory guidance and best practice.

    • Education

  • PhD in Pharmacy, Chemistry, Biochemistry or Biology

    • Specific Knowledge

  • In-depth understanding of the ADME processes applied to NCEs and in the screening strategies from feasibility to candidate nomination. Knowledge of the ADME/DMPK processes for NBEs is a plus.
  • Good knowledge of bioanalysis and expertise in the use of the LC-MS/MS platforms. Specific bioanalytical knowledge applied to both small and large molecules (e.g. using LBA) is a plus.
  • Experience in the use of pharmacokinetic analysis software, such us Phoenix, and good understanding of the PK and PK/PD principles to interpret results.
  • Good knowledge of the tools and strategies for human PK predictions based on preclinical data and in the mechanistic PK/PD data interpretation.
  • Additional knowledge in the use of tools for modeling and simulation of dynamic systems (such as SimBiology) is a plus.

    • Experience

  • 5+ years of experience in the field of ADME/DMPK/Bioanalysis of Small Molecule Drugs.
  • Experience or specific knowledge applied to the ADME/DMPK of therapeutic proteins is a plus.

    • Competencies

  • Teamwork and personal leadership.
  • Ability to work in a matrix environment, multi-task, meet deadlines and deal with evolving priorities.
  • Excellent communication and written skills in English

    • Values

  • Care: we listen & empathize, we value diverse perspectives & backgrounds and we help each other succeed.
  • Courage: we challenge the status quo, we take full ownership and we learn from our success & failures
  • Innovation: we put the patient and customer at the center, we create novel solutions and we empower entrepreneurial mindsets.
  • Simplicity: we act decisively and avoid over-analysis, we understand why before we act and we are agile & keep things simple.
  • Almirall

    Senior Scientist

    hace 2 días

    Almirall Girona, España

    Mission · Almirall is a global pharmaceutical company with a focus on Medical Dermatology. Our goal is to develop novel therapeutics to tackle unmet medical need in the fields of immune inflammatory skin diseases, rare skin diseases and non-melanoma skin cancers. · We are seekin ...

  • Almirall

    Senior Clinical Scientist

    hace 2 días

    Almirall Girona, España

    Mission · • The Senior Clinical Development Scientist is an important member of the Global Project Team, Strategic Clinical Team and Clinical Study Teams working cross functionally with other R&D and non-R&D departments such as Regulatory and Patient Safety, Disease Biology, Gl ...

  • fundcraft Holdco S.l

    Senior Data Scientist

    hace 2 semanas

    fundcraft Holdco S.l Girona, España

    **About fundcraft**: · fundcraft is a fast-growing, tech-powered fund services provider, aiming to revolutionise the fund management industry through our proprietary platform. Our dedicated team of financial experts, lawyers, tech developers, and data scientists are fully committ ...

  • PepsiCo

    Senior Data Scientist

    hace 1 día

    PepsiCo Cornellà del Terri, España De jornada completa

    Overview Global IBP · The Integrated Business Planning (IBP) process aims to transform business decision making that will result in profitable and sustainable growth balancing strategic, financial and operational objectives. It is a cross-functional, rolling planning process i ...

  • Almirall

    Senior Statistician

    hace 6 días

    Almirall Girona, España

    Mission · The Senior Statistician will be responsible of the design and statistics of clinical trials and clinical development projects within Almirall. The Senior Statistician will partner with senior scientists in clinical (Global Development and Global Medical Affairs), safet ...

  • fundcraft Holdco S.l

    Executive Assistant

    hace 3 semanas

    fundcraft Holdco S.l Girona, España De jornada completa

    About fundcraft: · fundcraft is a fast-growing, tech-powered fund services provider, aiming to revolutionise the fund management industry through our proprietary platform. Our dedicated team of financial experts, lawyers, tech developers, and data scientists are fully committed t ...

  • fundcraft Holdco S.l

    Executive Assistant

    hace 1 semana

    fundcraft Holdco S.l Girona, España De jornada completa

    About fundcraft: · fundcraft is a fast-growing, tech-powered fund services provider, aiming to revolutionise the fund management industry through our proprietary platform. Our dedicated team of financial experts, lawyers, tech developers, and data scientists are fully committed t ...

  • fundcraft Holdco S.l

    Accounting Trainee

    hace 3 semanas

    fundcraft Holdco S.l Girona, España

    **About fundcraft**: · fundcraft is a fast-growing start-up, aiming to revolutionise the fund management industry through our proprietary platform. We're building the digital infrastructure for asset managers. Our dedicated team of financial experts, lawyers, tech developers, and ...

  • fundcraft

    Accountant Trainee Girona

    hace 3 semanas

    fundcraft Girona, España Sin especificar

    About fundcraft · fundcraft is a fast-growing start-up, aiming to revolutionise the fund management industry through our proprietary platform. We're building the digital infrastructure for asset managers. Our dedicated team of financial experts, lawyers, tech developers, and data ...

  • fundcraft Holdco S.l

    Executive Assistant

    hace 3 semanas

    fundcraft Holdco S.l Girona, España

    **About fundcraft**: · fundcraft is a fast-growing, tech-powered fund services provider, aiming to revolutionise the fund management industry through our proprietary platform. Our dedicated team of financial experts, lawyers, tech developers, and data scientists are fully committ ...

  • fundcraft Holdco S.l

    Corporate Accountant

    hace 2 semanas

    fundcraft Holdco S.l Girona, España

    **About fundcraft**: · fundcraft is a fast-growing fintech/regtech company, aiming to revolutionise the fund industry by creating the digital infrastructure for asset managers. Our dedicated team of financial experts, lawyers, tech developers, and data scientists are fully commit ...

  • fundcraft Holdco S.l

    Product Owner

    hace 3 semanas

    fundcraft Holdco S.l Girona, España

    **About fundcraft**: · fundcraft is a fast-growing, tech-powered fund services provider, aiming to revolutionise the fund management industry through our proprietary platform. Our dedicated team of financial experts, lawyers, tech developers, and data scientists are fully committ ...

  • fundcraft Holdco S.l

    Executive Assistant

    hace 1 semana

    fundcraft Holdco S.l Girona, España

    **About fundcraft**: · fundcraft is a fast-growing, tech-powered fund services provider, aiming to revolutionise the fund management industry through our proprietary platform. Our dedicated team of financial experts, lawyers, tech developers, and data scientists are fully committ ...

  • fundcraft Holdco S.l

    Fund Services Senior Accountant

    hace 2 semanas

    fundcraft Holdco S.l Girona, España

    **About fundcraft**: · fundcraft is a fast-growing, tech-powered fund services provider, aiming to revolutionise the fund management industry through our proprietary platform. Our dedicated team of financial experts, lawyers, tech developers, and data scientists are fully committ ...

  • fundcraft Holdco S.l

    Fs Associate

    hace 1 día

    fundcraft Holdco S.l Girona, España

    **About fundcraft**: · fundcraft is a fast-growing, tech-powered fund services provider, aiming to revolutionise the fund management industry through our proprietary platform. Our dedicated team of financial experts, lawyers, tech developers, and data scientists are fully committ ...

  • fundcraft Holdco S.l

    Senior Scrum Master

    hace 2 semanas

    fundcraft Holdco S.l Girona, España

    **About fundcraft**: · fundcraft is a fast-moving fintech / regtech start-up with a dedicated team of investment fund experts, · developers and data scientists who believe in technology's disruptive impact. · We will leverage our different backgrounds to rethink and will reinvent ...